Try taking it right after you eat dinner. That is what my Dr advised me to do when I had issues and it helped soo much.

You have to work up to it. When I started, I had a quarter dose for a couple of weeks, then a half dose, then a 3/4 dose, then the full dose but I got stomach cramps so they put me on the slow release ones and they're much better. Now I just take one a day.

I had issues when I first took it so I was advised to take it at night. Also, see if they will try the slow release one. I'm on that now and it is much better!

I took mine at night when I went to bed to avoid the tummy issues. Also when I started my doc had me slowly introduce it to my system. 500mg a day per week then 1000 the next etc

I am on 500 right now, and my doctor is going to increase it up to 1000 eventually. It made me feel really sick, so I started to eat every 3-4 hours (small amnts) which helps with the nausea. If I tried to eat anything more than a small amount of carbs it made my stomach hurt too. Now my body is used to the dosage, so I don't have as many problems... well, I still do with carbs, but not too much other issues.