I'm about to get gastric bypass in December and I plan on going back on it after my surgery.

From what I've read, it can. But if you do gain weight, it may or may not be much. The prescription information says that on average someone can gain anywhere from 3 to 5 pounds in a year. It really just depends. I can't say whether I've gained weight on it with having PCOS.

@A myPCOSteam Member does it make you gain weight? I'm scared of the weight gain.

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A myPCOSt...

Well I take the Depo shot. My endocrinologist wants me to stop taking bc but my on/gyn doesn't see a problem with it. The only thing is that I have to tell my endocrinologist when I'm almost due for another shot so I can come in and get my testosterone tested, so that my results will be accurate.