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Real members of myPCOSteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

does anyone take wellbutrin or something like it with metformin to help with depression?

A myPCOSteam Member asked a question 💭
San Benito, TX

I suffer from huge ups and downs with depression and my mother wants me to take something for it and I used to take Wellbutrin but I felt it didn't work, i was hoping that maybe anyone might be taking something like it and wanted to know if it is helping you.

February 16, 2017
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Answer Summary

Members shared their personal experiences with antidepressants and metformin to help someone managing depression alongside PCOS. Several... Read more

Members shared their personal experiences with antidepressants and metformin to help someone managing depression alongside PCOS. Several members described using medications like Wellbutrin, Zoloft, Prozac, Cymbalta, Celexa, and Lexapro alongside metformin, with many finding relief after trying a few different options since some, like Wellbutrin, caused side effects including irritability or a racing heart. A recurring theme was that finding the right combination takes time, and many members encouraged seeking support from a doctor while reassuring others that depression linked to PCOS is a real and shared experience.

A myPCOSteam Member

I take Cymbalta with Metformin. That has worked best for me through the yeara

April 13, 2019
A myPCOSteam Member

I take Fluoxetine (Prozac) and Metformin. I've been taking Fluoxetine for about 6 years now. It helps tremendously! I'm alot calmer and I don't get anxious as I used to.

March 15, 2018
A myPCOSteam Member

I take Wellbutrin and Metformin...
I was taking Wellbutrin before TCC, and stopped when we conceived and didn't go back on even after a miscarriage.
Then after about a year without conceiving again and then learning I had PCOS, it triggered another depressive episode.
I went back on Wellbutrin about 6 months ago, and within 1 week of taking it again...it was literally like someone turned the lights back on the world for me. Things literally looked brighter, I plan to just stay on it until I'm pregnant.
It's been about 6 months on Metformin as well, and with a balanced diet and just a few walks a week; I've lost 19 lbs.

April 9, 2017
A myPCOSteam Member

I take 100mg sertraline tablets for my depression, but it was diagnosed before I was diagnosed with PCOS.
I'm also on 500mg metformin twice a day and simvastatins, 20mg.

August 7, 2023
A myPCOSteam Member

I havent been diagnosed with depression but i know i have it. But i didnt know it was a symptom of pcos.

September 5, 2019

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