I take Cymbalta with Metformin. That has worked best for me through the yeara

I take Fluoxetine (Prozac) and Metformin. I've been taking Fluoxetine for about 6 years now. It helps tremendously! I'm alot calmer and I don't get anxious as I used to.

I take Wellbutrin and Metformin...
I was taking Wellbutrin before TCC, and stopped when we conceived and didn't go back on even after a miscarriage.
Then after about a year without conceiving again and then learning I had PCOS, it triggered another depressive episode.
I went back on Wellbutrin about 6 months ago, and within 1 week of taking it again...it was literally like someone turned the lights back on the world for me. Things literally looked brighter, I plan to just stay on it until I'm pregnant.
It's been about 6 months on Metformin as well, and with a balanced diet and just a few walks a week; I've lost 19 lbs.

I havent been diagnosed with depression but i know i have it. But i didnt know it was a symptom of pcos.

I’m on cetalopram with my metformin. This seems to be the best combination for me.