Assuming you have PCOS I would try changing primary care doctors. Try a holistic, naturapathic or Intergrative Care doctor. Most important call around and ask if the doctor test cortisol levels and if they know about the MTHFR gene mutation. Most traditional doctors do not see the adrenal glands as important... They are wrong the adrenal are very important. MTHFR gene mutation is the most current medical information available dealing with PCOS. If the doctor doesn't know what it is, they are not up to date on the information that can help you. Your doctors are as only as good as the knowledge they have, if they don't know there is information out there, they can not help you effectively.